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    J Autoimmun. 2008 Nov;31(3):216-8. Epub 2008 May 27.

    Autoimmunity and persistent viral infection: two sides of the same coin?

    Source

    Diamantina Institute for Cancer, Immunology and Metabolic Medicine, The University of Queensland, Queensland 4102, Australia. i.frazer@uq.edu.au

    Abstract

    Organ specific autoimmunity follows induction and perpetuation of cell mediated immune effector responses to antigens expressed by somatic cells of the target organ, and clearance of persistent viral infection requires a similar immune response. Research on regulators of innate and adaptive immunity that hinder clearance of viral infection may therefore shed light on genetic factors predisposing to organ specific autoimmunity. This article discusses Ian Mackay's interests in autoimmunity when I was his assistant physician, and their influence on my group's subsequent research on persistent viral infection.

    PMID:
    18502097
    [PubMed - indexed for MEDLINE]

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