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Regul Pept. 2008 Oct 9;150(1-3):33-7. doi: 10.1016/j.regpep.2008.04.003. Epub 2008 Apr 13.

The transcriptional co-activator PGC-1alpha up regulates apelin in human and mouse adipocytes.

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  • 1Institut National de la Santé et de la Recherche Médicale, U858, Toulouse, France. mazzucotelli@free.fr


By using pangenomic microarray, we identified apelin as a unique adipokine up regulated by the transcriptional co-activator peroxisome proliferator-activated receptor gamma (PPARgamma) co-activator 1alpha (PGC-1alpha) in human white adipocytes. We investigated its regulation in vitro and in vivo. Overexpression of PGC-1alpha by adenovirus in human adipocytes induces apelin expression and secretion. Pharmacological induction of cAMP, an upstream regulator of endogenous PGC-1alpha expression, up regulates apelin gene expression and also apelin secretion in human and mice adipocytes. Moreover, during cold exposure in mice, a physiological situation known to induce both cAMP and PGC-1alpha, apelin expression in adipocytes and plasma levels were increased. This is the first demonstration that PGC-1alpha is involved in the regulation of an adipokine gene expression and release.

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