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    Mutagenesis. 2008 Sep;23(5):367-70. Epub 2008 May 21.

    The effects of Atm haploinsufficiency on mutation rate in the mouse germ line and somatic tissue.

    Ahuja AK, Barber RC, Hardwick RJ, Weil MM, Genik PC, Brenner DJ, Dubrova YE.

    Department of Genetics, University of Leicester, Leicester LE1 7RH, UK.

    Using single-molecule polymerase chain reaction, the frequency of spontaneous and radiation-induced mutation at an expanded simple tandem repeat (ESTR) locus was studied in DNA samples extracted from sperm and bone marrow of Atm knockout (Atm(+/-)) heterozygous male mice. The frequency of spontaneous mutation in sperm and bone marrow in Atm(+/-) males did not significantly differ from that in wild-type BALB/c mice. Acute exposure to 1 Gy of gamma-rays did not affect ESTR mutation frequency in bone marrow and resulted in similar increases in sperm samples taken from Atm(+/-) and BALB/c males. Taken together, these results suggest that the Atm haploinsufficiency analysed in our study does not affect spontaneous and radiation-induced ESTR mutation frequency in mice.

    PMID: 18499649 [PubMed - indexed for MEDLINE]

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