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Clin Oncol (R Coll Radiol). 2008 Aug;20(6):433-47. doi: 10.1016/j.clon.2008.04.005. Epub 2008 May 21.

Pathology of uterine malignancies.

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  • Department of Histopathology, Leicester Royal Infirmary, Infirmary Square, Leicester, UK. laurence.brown@uhl-tr.nhs.uk


This overview covers epithelial, stromal and mesenchymal malignancies of the body of the uterus, excluding the cervix. The distinction of type I and type II endometrial adenocarcinoma with the morphological variants of this tumour is discussed and some molecular aspects are explored. The concept of carcinosarcoma representing a metaplastic adenocarcinoma of the endometrium that behaves more like a carcinoma than a sarcoma is explained. Some types of mixed epithelial and stromal neoplasm are described and contrasted with carcinosarcoma. The concept of stromal sarcoma and high-grade uterine sarcoma is described and an outline of malignant smooth muscle tumours of the uterus includes a description of smooth muscle tumours of uncertain malignant potential and worrying benign smooth muscle lesions.

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