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Clin Oncol (R Coll Radiol). 2008 Aug;20(6):433-47. doi: 10.1016/j.clon.2008.04.005. Epub 2008 May 21.

Pathology of uterine malignancies.

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  • 1Department of Histopathology, Leicester Royal Infirmary, Infirmary Square, Leicester, UK.


This overview covers epithelial, stromal and mesenchymal malignancies of the body of the uterus, excluding the cervix. The distinction of type I and type II endometrial adenocarcinoma with the morphological variants of this tumour is discussed and some molecular aspects are explored. The concept of carcinosarcoma representing a metaplastic adenocarcinoma of the endometrium that behaves more like a carcinoma than a sarcoma is explained. Some types of mixed epithelial and stromal neoplasm are described and contrasted with carcinosarcoma. The concept of stromal sarcoma and high-grade uterine sarcoma is described and an outline of malignant smooth muscle tumours of the uterus includes a description of smooth muscle tumours of uncertain malignant potential and worrying benign smooth muscle lesions.

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