Gastroenterol Clin North Am. 2008 Jun;37(2):397-410, vi-vii.

Enteric autoantibodies and gut motility disorders.

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Mayo Clinic, Rochester, MN 55905, USA.

Abstract

Increasing evidence suggests that a subset of gastrointestinal motility disorders is associated with the presence of circulating antibodies. These antibodies are directed against various molecular targets, the best known being anti-neuronal nuclear antibody (ANNA-1 or anti-Hu) associated with paraneoplastic motility disorders. There is also evidence that the presence of distinct autoantibody profiles is associated with non-paraneoplastic motility disorders. This review focuses on the types of antibodies associated with gastrointestinal motility disorders and the significance of these antibodies. Algorithms are suggested for the work-up and treatment of patients with circulating antibodies associated with gastrointestinal motility disorders.

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PMCID:: PMC2448392

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