Your browser version may not work well with NCBI's Web applications. More information here...
1: Gastroenterol Clin North Am. 2008 Jun;37(2):397-410, vi-vii.Click here to read Click here to read Links

Enteric autoantibodies and gut motility disorders.

Kashyap P, Farrugia G.

Mayo Clinic, Rochester, MN 55905, USA.

Increasing evidence suggests that a subset of gastrointestinal motility disorders is associated with the presence of circulating antibodies. These antibodies are directed against various molecular targets, the best known being anti-neuronal nuclear antibody (ANNA-1 or anti-Hu) associated with paraneoplastic motility disorders. There is also evidence that the presence of distinct autoantibody profiles is associated with non-paraneoplastic motility disorders. This review focuses on the types of antibodies associated with gastrointestinal motility disorders and the significance of these antibodies. Algorithms are suggested for the work-up and treatment of patients with circulating antibodies associated with gastrointestinal motility disorders.

PMID: 18499027 [PubMed - indexed for MEDLINE]

PMCID: PMC2448392