Addict Sci Clin Pract. 2008 Jun;4(2):28-35.

The search for medications to treat stimulant dependence.

Source

University of Pennsylvania School of Medicine and Treatment Research Center, Philadelphia, Pennsylvania 19104, USA. kampman_k@mail.trc.upenn.edu

Abstract

Progress in understanding the neurobiology of stimulant dependence has enabled researchers to identify medications whose pharmacological effects suggest that they might help patients initiate abstinence or avoid relapse. Several of these medications and a vaccine have shown encouraging results in controlled clinical trials with cocaine-dependent patients. The search for a medical treatment for methamphetamine dependence started more recently, due to the later emergence of this epidemic, but at least one candidate medication has shown promise in early clinical testing. Treatment approaches that combine efficacious medications and empirically proven behavioral interventions, such as voucher-based reinforcement therapy, will almost certainly produce the best results.

Comment in

Addict Sci Clin Pract. 2008 Jun;4(2):36-8.

PMID:: 18497715; [PubMed - indexed for MEDLINE]
PMCID:: PMC2797110

Free PMC Article

Images from this publication.See all images (1) Free text

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Molecular Biology Databases

Supplemental Content

Icon for National Institute on Drug Abuse

Save items

Related citations in PubMed

Response: anticipating new medications. [Addict Sci Clin Pract. 2008]
Response: anticipating new medications.
Bogenschutz MP, DeMarzo LJ, Roll J. Addict Sci Clin Pract. 2008 Jun; 4(2):36-8.
Review Novel medications to treat addictive disorders. [Curr Psychiatry Rep. 2008]
Review Novel medications to treat addictive disorders.
Montoya ID, Vocci F. Curr Psychiatry Rep. 2008 Oct; 10(5):392-8.
Review Use of stimulants to treat cocaine and methamphetamine abuse. [Curr Psychiatry Rep. 2008]
Review Use of stimulants to treat cocaine and methamphetamine abuse.
Moeller FG, Schmitz JM, Herin D, Kjome KL. Curr Psychiatry Rep. 2008 Oct; 10(5):385-91.
Review Management of methamphetamine abuse and dependence. [Curr Psychiatry Rep. 2006]
Review Management of methamphetamine abuse and dependence.
Ling W, Rawson R, Shoptaw S, Ling W. Curr Psychiatry Rep. 2006 Oct; 8(5):345-54.
A double-blind, placebo-controlled trial of amantadine, propranolol, and their combination for the treatment of cocaine dependence in patients with severe cocaine withdrawal symptoms. [Drug Alcohol Depend. 2006]
A double-blind, placebo-controlled trial of amantadine, propranolol, and their combination for the treatment of cocaine dependence in patients with severe cocaine withdrawal symptoms.
Kampman KM, Dackis C, Lynch KG, Pettinati H, Tirado C, Gariti P, Sparkman T, Atzram M, O'Brien CP. Drug Alcohol Depend. 2006 Nov 8; 85(2):129-37. Epub 2006 May 11.

See reviews... See all...

Cited by 2 PubMed Central articles

A novel photoaffinity ligand for the dopamine transporter based on pyrovalerone. [Bioorg Med Chem. 2009]
A novel photoaffinity ligand for the dopamine transporter based on pyrovalerone.
Lapinsky DJ, Aggarwal S, Huang Y, Surratt CK, Lever JR, Foster JD, Vaughan RA. Bioorg Med Chem. 2009 Jun 1; 17(11):3770-4. Epub 2009 May 3.
Response: anticipating new medications. [Addict Sci Clin Pract. 2008]
Response: anticipating new medications.
Bogenschutz MP, DeMarzo LJ, Roll J. Addict Sci Clin Pract. 2008 Jun; 4(2):36-8.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The search for medications to treat stimulant dependence.
The search for medications to treat stimulant dependence.
Addict Sci Clin Pract. 2008 Jun ;4(2):28-35.

PubMed
Low prior + frightening implications = inflammatory epidemiology?
Low prior + frightening implications = inflammatory epidemiology?
Epidemiology. 2008 Jul ;19(4):534-5.

PubMed
Carbon monoxide inhalation reduces pulmonary inflammatory response during cardio...
Carbon monoxide inhalation reduces pulmonary inflammatory response during cardiopulmonary bypass in pigs.
Anesthesiology. 2008 Jun ;108(6):1025-36.

PubMed
MicroRNA-34 mediates AR-dependent p53-induced apoptosis in prostate cancer.
MicroRNA-34 mediates AR-dependent p53-induced apoptosis in prostate cancer.
Cancer Biol Ther. 2008 Aug ;7(8):1288-96. Epub 2008 Aug 13 .

PubMed
Rapid spontaneous remission of a spontaneous spinal chronic subdural hematoma in...
Rapid spontaneous remission of a spontaneous spinal chronic subdural hematoma in a child.
Neurol Med Chir (Tokyo). 2008 May ;48(5):231-4.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

The search for medications to treat stimulant dependence.

Source

Abstract

Comment in

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 2 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information