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Science. 2008 May 23;320(5879):1012; author reply 1012. doi: 10.1126/science.1152366.

Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis".

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  • 1Centre for Diabetes and Endocrinology, Department of Medicine, University College London, Rayne Institute, 5 University Street, London WC1E 6JJ, UK.


Taguchi et al. (Reports, 20 July 2007, p. 369) reported that mice heterozygous for a null mutation in insulin receptor substrate-2 (Irs2) display a 17% increase in median life span. However, using the same mouse model, we find no evidence for life-span extension and suggest that the findings of Taguchi et al. were due to atypical life-span profiles in their study animals.

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