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    Ann Neurol. 2008 Jun;63(6):798-802. doi: 10.1002/ana.21383.

    Cystatin C as a marker of cognitive function in elders: findings from the health ABC study.

    Yaffe K, Lindquist K, Shlipak MG, Simonsick E, Fried L, Rosano C, Satterfield S, Atkinson H, Windham BG, Kurella-Tamura M.

    Source

    Department of Psychiatry, School of Medicine, University of California, San Francisco, CA 94121, USA. kristine.yaffe@ucsf.edu

    Abstract

    We determined whether serum cystatin C, a novel measure of kidney function that colocalizes with brain beta-amyloid, is associated with cognition among 3,030 elders. Those with high cystatin C (n = 445; 15%) had worse baseline scores on Modified Mini-Mental State Examination or Digit Symbol Substitution Test (p <or= 0.02) compared with those with intermediate/low level and 7 years greater decline (p <or= 0.04). Incident cognitive impairment (decline >or=1.0 standard deviation) was greatest among those with high cystatin C (Modified Mini-Mental State Examination: 38 vs 25%; adjusted odds ratio, 1.92; 95% confidence interval, 1.37-2.69; Digit Symbol Substitution: 38 vs 26%; odds ratio, 1.54; 95% confidence interval, 1.10-2.15).

    PMID:
    18496846
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2584446
    Free PMC Article

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