PREMATURE VASCULAR SENESCENCE IN METABOLIC SYNDROM...[Drug Discov Today Ther Strateg. 2007]

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1: Drug Discov Today Ther Strateg. 2007;4(1):93-99. Links

PREMATURE VASCULAR SENESCENCE IN METABOLIC SYNDROME: COULD IT BE PREVENTED AND REVERSED BY A SELENORGANIC ANTIOXIDANT AND PEROXYNITRITE SCAVENGER EBSELEN?

Chen J, Park HC, Patschan S, Brodsky SV, Gealikman O, Kuo MC, Li H, Addabbo F, Zhang F, Nasjletti A, Gross SS, Goligorsky MS.

Departments of Medicine and Pharmacology, Renal Research Institute, New York Medical College, Valhalla, NY and Department of Pharmacology, Weill Medical College at Cornell University, New York, NY.

PMID: 18496595 [PubMed]

PMCID: PMC2390842

Prevention and reversal of premature endothelial cell senescence and vasculopathy in obesity-induced diabetes by ebselen.
Circ Res. 2004 Feb 20; 94(3):377-84. Epub 2003 Dec 11.

[Circ Res. 2004]
Glycated collagen I induces premature senescence-like phenotypic changes in endothelial cells.
Circ Res. 2002 Jun 28; 90(12):1290-8.

[Circ Res. 2002]
Nephropathy in Zucker diabetic fat rat is associated with oxidative and nitrosative stress: prevention by chronic therapy with a peroxynitrite scavenger ebselen.
J Am Soc Nephrol. 2004 Sep; 15(9):2391-403.

[J Am Soc Nephrol. 2004]
ReviewEbselen: a thioredoxin reductase-dependent catalyst for alpha-tocopherol quinone reduction.
Toxicol Appl Pharmacol. 2005 Sep 1; 207(2 Suppl):103-9.

[Toxicol Appl Pharmacol. 2005]
ReviewEbselen as a glutathione peroxidase mimic and as a scavenger of peroxynitrite.
Adv Pharmacol. 1997; 38:229-46.

[Adv Pharmacol. 1997]
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