Arch Intern Med. 1991 Apr;151(4):781-3.

Intravenous methylphenidate abuse. Prototype for prescription drug abuse.

Source

Department of Medicine, Francis Scott Key Medical Center, Baltimore, Md.

Abstract

Data are presented from a case series of 22 patients who abused methylphenidate hydrochloride (Ritalin-SR). The abuse pattern and symptoms of toxicity were similar to that seen with cocaine hydrochloride and amphetamine sulfate addiction; yet, the morbidity and mortality seen in this case series were greater than usual for a group of patients involved in intravenous drug abuse. We describe the characteristics of the methylphenidate abuse syndrome in terms of the pharmacology of methylphenidate, the constituents of the Ritalin-SR preparation, and the disease of chemical dependence. We propose solutions to the problem of methylphenidate abuse.

PMID:: 1849397; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

Methylphenidate

LinkOut - more resources

Full Text Sources

Molecular Biology Databases

METHYLPHENIDATE - HSDB

Supplemental Content

Icon for Silverchair Information Systems

Save items

Related citations in PubMed

[Two cases of chronic respiratory failure in intravenous methylphenidate (Ritalin) abusers]. [Nihon Kyobu Shikkan Gakkai Zas...]
[Two cases of chronic respiratory failure in intravenous methylphenidate (Ritalin) abusers].
Kajiki A, Tsuda T, Yamazaki H, Kido M. Nihon Kyobu Shikkan Gakkai Zasshi. 1992 Jul; 30(7):1290-5.
IV pentazocine/methylphenidate abuse--the clinical toxicity of another Ts and blues combination. [J Toxicol Clin Toxicol. 1994]
IV pentazocine/methylphenidate abuse--the clinical toxicity of another Ts and blues combination.
Carter HS, Watson WA. J Toxicol Clin Toxicol. 1994; 32(5):541-7.
Successful lung transplantation for talcosis secondary to intravenous abuse of oral drug. [Int J Chron Obstruct Pulmon Di...]
Successful lung transplantation for talcosis secondary to intravenous abuse of oral drug.
Shlomi D, Shitrit D, Bendayan D, Sahar G, Shechtman Y, Kramer MR. Int J Chron Obstruct Pulmon Dis. 2008; 3(2):327-30.
Review Assessing the abuse potential of methylphenidate in nonhuman and human subjects: a review. [Pharmacol Biochem Behav. 2001]
Review Assessing the abuse potential of methylphenidate in nonhuman and human subjects: a review.
Kollins SH, MacDonald EK, Rush CR. Pharmacol Biochem Behav. 2001 Mar; 68(3):611-27.
Review Methylphenidate and substance abuse: a review of pharmacology, animal, and clinical studies. [J Atten Disord. 2002]
Review Methylphenidate and substance abuse: a review of pharmacology, animal, and clinical studies.
Huss M, Lehmkuhl U. J Atten Disord. 2002; 6 Suppl 1:S65-71.

See reviews... See all...

Cited by 6 PubMed Central articles

Illicit methylphenidate use among Iranian medical students: prevalence and knowledge. [Drug Des Devel Ther. 2011]
Illicit methylphenidate use among Iranian medical students: prevalence and knowledge.
Habibzadeh A, Alizadeh M, Malek A, Maghbooli L, Shoja MM, Ghabili K. Drug Des Devel Ther. 2011 Feb 3; 5:71-6. Epub 2011 Feb 3.
Conditioned place preference and locomotor activity in response to methylphenidate, amphetamine and cocaine in mice lacking dopamine D4 receptors. [J Psychopharmacol. 2010]
Conditioned place preference and locomotor activity in response to methylphenidate, amphetamine and cocaine in mice lacking dopamine D4 receptors.
Thanos PK, Bermeo C, Rubinstein M, Suchland KL, Wang GJ, Grandy DK, Volkow ND. J Psychopharmacol. 2010 Jun; 24(6):897-904. Epub 2009 Mar 12.
Methylphenidate-induced dendritic spine formation and DeltaFosB expression in nucleus accumbens. [Proc Natl Acad Sci U S A. 2009]
Methylphenidate-induced dendritic spine formation and DeltaFosB expression in nucleus accumbens.
Kim Y, Teylan MA, Baron M, Sands A, Nairn AC, Greengard P. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2915-20. Epub 2009 Feb 6.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Intravenous methylphenidate abuse. Prototype for prescription drug abuse.
Intravenous methylphenidate abuse. Prototype for prescription drug abuse.
Arch Intern Med. 1991 Apr ;151(4):781-3.

PubMed
Two new megastigmane glycosides, physanosides A and B, from Physalis alkekengi L...
Two new megastigmane glycosides, physanosides A and B, from Physalis alkekengi L. var. franchetii, and their effect on NO release in macrophages.
Chem Biodivers. 2008 May ;5(5):758-63.

PubMed
New directions in head and neck imaging.
New directions in head and neck imaging.
J Surg Oncol. 2008 Jun 15 ;97(8):644-8.

PubMed
Evaluating the differential roles of the dorsal dentate gyrus, dorsal CA3, and d...
Evaluating the differential roles of the dorsal dentate gyrus, dorsal CA3, and dorsal CA1 during a temporal ordering for spatial locations task.
Hippocampus. 2008 ;18(9):955-64.

PubMed
Collagen nanofibres are a biomimetic substrate for the serum-free osteogenic dif...
Collagen nanofibres are a biomimetic substrate for the serum-free osteogenic differentiation of human adipose stem cells.
J Tissue Eng Regen Med. 2008 Jun ;2(4):210-20.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: