Format

Send to:

Choose Destination
See comment in PubMed Commons below
JAMA. 2008 May 21;299(19):2294-303. doi: 10.1001/jama.299.19.2294.

Improvement in process of care and outcome after a multicenter severe sepsis educational program in Spain.

Collaborators (130)

Artigas A, Blanco J, Gonzalez-Díaz G, Ferrer R, Garnacho-Montero J, Ibáñez J, Levy MM, Palencia E, Quintana M, de la Torre MV, Artigas A, Ferrer R, Levy MM, Blanco J, Gonzalez-Díaz G, Ferrer R, Garnacho-Montero J, Ibáñez J, Palencia E, Quintana M, de la Torre MV, Gomà G, Suarez D, Real J, Martin I, Navas A, Ferrer R, Artigas A, Alvarez M, Sirvent JM, Herranz Ulldemolins S, Galdós P, Balziscueta G, Marco P, Azkarate I, Sierra R, Izua JJ, Castaño J, Ambrós A, Ortega J, Corcoles V, Tamayo L, Carriedo D, Llorente M, Merino P, Bustamante E, Palencia E, García Olivares P, Santa Teresa Zamarro P, Pérez C, Renedo A, Nicolás-Franco S, Salomé Sánchez M, Gil FJ, Gómez MJ, Piacentini E, Loza A, Ibáñez J, Rodríguez S, Berezo JA, Blanco J, Gabán A, López Cambra MJ, Tallet A, Martínez M, Fernández JA, Callejo F, López Pueyo MJ, Gandía F, Fernández J, Ballesteros JC, Antuña MT, Herrero S, Valledor M, Gutierrez J, Pérez C, Rodríguez O, Dominguez R, Peinado J, de la Torre MV, Salazar C, de la Cruz Martín M, Ramon J, Iglesias Llaca F, Forcelledo Espina L, Taboada Costa F, Gonzalo Guerra JA, Guerrero FJ, Cañada F, Balaguer M, Mertín I, López C, Sánchez D, Costa J, Calizaya M, Arenaza A, Morillo A, Del Toro D, Guzman T, Blesa A, Martínez F, Moneo A, Broch J, Camacho JA, Garcia FJ, Pérez XL, Garcia N, Ruiz JC, Caballero J, Francisco E, Requena T, Ruiz A, Bóveda JL, Soto JM, Tormo C, Blancas R, Quintana M, Taberna MA, Añon JM, Aranjo JB, Rodríguez M, Garcia JM, Rodríguez I, Huertos J, Ortiz C, Yuste E, Machado JF, Ocaña D, Vegas R, Vallejo L.

Abstract

CONTEXT:

Concern exists that current guidelines for care of patients with severe sepsis and septic shock are followed variably, possibly due to a lack of adequate education.

OBJECTIVE:

To determine whether a national educational program based on the Surviving Sepsis Campaign guidelines affected processes of care and hospital mortality for severe sepsis.

DESIGN, SETTING, AND PATIENTS:

Before and after design in 59 medical-surgical intensive care units (ICUs) located throughout Spain. All ICU patients were screened daily and enrolled if they fulfilled severe sepsis or septic shock criteria. A total of 854 patients were enrolled in the preintervention period (November-December 2005), 1465 patients during the postintervention period (March-June 2006), and 247 patients during the long-term follow-up period 1 year later (November-December 2006) in a subset of 23 ICUs.

INTERVENTION:

The educational program consisted of training physicians and nursing staff from the emergency department, wards, and ICU in the definition, recognition, and treatment of severe sepsis and septic shock as outlined in the guidelines. Treatment was organized in 2 bundles: a resuscitation bundle (6 tasks to begin immediately and be accomplished within 6 hours) and a management bundle (4 tasks to be completed within 24 hours).

MAIN OUTCOME MEASURES:

Hospital mortality, differences in adherence to the bundles' process-of-care variables, ICU mortality, 28-day mortality, hospital length of stay, and ICU length of stay.

RESULTS:

Patients included before and after the intervention were similar in terms of age, sex, and Acute Physiology and Chronic Health Evaluation II score. At baseline, only 3 process-of-care measurements (blood cultures before antibiotics, early administration of broad-spectrum antibiotics, and mechanical ventilation with adequate inspiratory plateau pressure) we had compliance rates higher than 50%. Patients in the postintervention cohort had a lower risk of hospital mortality (44.0% vs 39.7%; P = .04). The compliance with process-of-care variables also improved after the intervention in the sepsis resuscitation bundle (5.3% [95% confidence interval [CI], 4%-7%] vs 10.0% [95% CI, 8%-12%]; P < .001) and in the sepsis management bundle (10.9% [95% CI, 9%-13%] vs 15.7% [95% CI, 14%-18%]; P = .001). Hospital length of stay and ICU length of stay did not change after the intervention. During long-term follow-up, compliance with the sepsis resuscitation bundle returned to baseline but compliance with the sepsis management bundle and mortality remained stable with respect to the postintervention period.

CONCLUSIONS:

A national educational effort to promote bundles of care for severe sepsis and septic shock was associated with improved guideline compliance and lower hospital mortality. However, compliance rates were still low, and the improvement in the resuscitation bundle lapsed by 1 year.

PMID:
18492971
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Write to the Help Desk