Display Settings:

Format

Send to:

Choose Destination
Nucleic Acids Res. 2008 Jul 1;36(Web Server issue):W47-54. doi: 10.1093/nar/gkn285. Epub 2008 May 20.

Superimpose: a 3D structural superposition server.

Author information

  • 1Charité-Universitätsmedizin Berlin, Structural Bioinformatics Group, Arnimallee 22, 14195 Berlin, Germany.

Abstract

The Superimposé webserver performs structural similarity searches with a preference towards 3D structure-based methods. Similarities can be detected between small molecules (e.g. drugs), parts of large structures (e.g. binding sites of proteins) and entire proteins. For this purpose, a number of algorithms were implemented and various databases are provided. Superimposé assists the user regarding the selection of a suitable combination of algorithm and database. After the computation on our server infrastructure, a visual assessment of the results is provided. The structure-based in silico screening for similar drug-like compounds enables the detection of scaffold-hoppers with putatively similar effects. The possibility to find similar binding sites can be of special interest in the functional analysis of proteins. The search for structurally similar proteins allows the detection of similar folds with different backbone topology. The Superimposé server is available at: http://bioinformatics.charite.de/superimpose.

PMID:
18492720
[PubMed - indexed for MEDLINE]
PMCID:
PMC2447795
Free PMC Article

Images from this publication.See all images (4)Free text

Figure 1.
Figure 2.
Figure 3.
Figure 4.
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Write to the Help Desk