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1: J Pediatr. 2008 Jun;152(6):850-3. Epub 2008 Jan 22.Click here to read Links
Comment in:
J Pediatr. 2009 Feb;154(2):307; author reply 307-8.

Pneumococcal pneumonia in hospitalized Uruguayan children and potential prevention with different vaccine formulations.

Hortal M, Sehabiague G, Camou T, Iraola I, Estevan M, Pujadas M.

National Child Health Program, Ministry of Health, Children's Hospital, Montevideo, Uruguay. mhortal@st.com.uy

OBJECTIVES: To provide information on pneumococcal pneumonias, on their associated serotypes, and to estimate the coverage potentially afforded by antipneumococcal vaccines. STUDY DESIGN: A retrospective study (2000 to 2004) was performed of patients with pneumococcal pneumonia aged 0 to 14 years admitted to the National Reference Children's Hospital in Uruguay. Selected clinical data, radiographic interpretation, and microbiologic reports were obtained for analysis. RESULTS: Of 410 enrolled patients, 384 had consolidated pneumonia/pleural effusion and 26 had infiltrates without consolidation: Pneumococcus was identified in blood or in pleural fluid of 387 patients; 21 serotypes were identified. The most frequent serotypes in decreasing order were serotypes 14, 1, 5, 3, 9V, 6B, and 7F. Forty-eight percent of invasive Streptococcus pneumoniae isolates were obtained from children younger than 24 months. For this group, the 7-valent vaccine would cover 60%, but a 10-valent vaccine would cover 83.8%. CONCLUSIONS: This study provides information on pneumonia of proven S. pneumoniae causes and their associated serotypes, enabling estimation of potential effect of pneumococcal conjugate vaccines.

PMID: 18492530 [PubMed - indexed for MEDLINE]

Patient Drug Information

  • Pneumococcal Polysaccharide Vaccine (Pneumovax® 23)

    Pneumococcal disease is caused byStreptococcus pneumoniae bacteria. It is a leading cause of vaccine-preventable illness and death in the United States. Anyone can get pneumococcal disease, but some people are at greater...

  • Pneumococcal Conjugate Vaccine (Prevnar® )

    Infection withStreptococcus pneumoniae bacteria can cause serious illness and death. Invasive pneumococcal disease is responsible for about 200 deaths each year among children under 5 years old. It is the leading cause o...

  • Source: AHFS Consumer Medication Information