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Primary structure and functional expression from complementary DNA of a brain calcium channel.
Mori Y,
Friedrich T,
Kim MS,
Mikami A,
Nakai J,
Ruth P,
Bosse E,
Hofmann F,
Flockerzi V,
Furuichi T, et al.
Department of Medical Chemistry, Kyoto University Faculty of Medicine, Japan.
The primary structure of a voltage-dependent calcium channel from rabbit brain has been deduced by cloning and sequencing the complementary DNA. Calcium channel activity expressed from the cDNA is dramatically increased by coexpression of the alpha 2 and beta subunits, known to be associated with the dihydropyridine receptor. This channel is a high voltage-activated calcium channel that is insensitive both to nifedipine and to omega-conotoxin. We suggest that it is expressed predominantly in cerebellar Purkinje cells and granule cells.
PMID: 1849233 [PubMed - indexed for MEDLINE]
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Cited by 89 PubMed Central articles
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Orientation of the calcium channel beta relative to the alpha(1)2.2 subunit is critical for its regulation of channel activity.
Vitko I, Shcheglovitov A, Baumgart JP, Arias-Olguín II, Murbartián J, Arias JM, Perez-Reyes E.
PLoS One. 2008; 3(10):e3560. Epub 2008 Oct 29.
[PLoS One. 2008]
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The stargazin-related protein gamma 7 interacts with the mRNA-binding protein heterogeneous nuclear ribonucleoprotein A2 and regulates the stability of specific mRNAs, including CaV2.2.
Ferron L, Davies A, Page KM, Cox DJ, Leroy J, Waithe D, Butcher AJ, Sellaturay P, Bolsover S, Pratt WS, et al.
J Neurosci. 2008 Oct 15; 28(42):10604-17.
[J Neurosci. 2008]
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Performances in cerebellar and neuromuscular transmission tests are correlated in migraine with aura.
Ambrosini A, Sándor PS, De Pasqua V, Pierelli F, Schoenen J.
J Headache Pain. 2008 Feb; 9(1):29-32. Epub 2008 Feb 5.
[J Headache Pain. 2008]
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