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Genome Biol. 2008;9(5):221. doi: 10.1186/gb-2008-9-5-221. Epub 2008 May 9.

A role for Numb in p53 stabilization.

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  • 1The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow, UK.

Abstract

The cell-fate determinant Numb has recently been shown to help activate the tumor suppressor protein p53. Loss of Numb in breast cancers would result, therefore, in both the activation of the potential oncogene Notch and the diminution of tumor suppression by p53.

PMID:
18492217
[PubMed - indexed for MEDLINE]
PMCID:
PMC2441455
Free PMC Article
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