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Eur J Heart Fail. 2008 Jun;10(6):587-93. doi: 10.1016/j.ejheart.2008.04.008. Epub 2008 May 19.

The effect of Crataegus oxycantha Special Extract WS 1442 on clinical progression in patients with mild to moderate symptoms of heart failure.

Author information

  • 1Department of Family Medicine, University of Michigan, Ann Arbor, MI 48104, USA. szick@umich.edu <szick@umich.edu>

Abstract

AIM:

To examine whether hawthorn (Crataegus Special Extract WS 1442 {CSE}) inhibits progression in heart failure (HF) patients.

METHODS:

We performed a retrospective analysis of data from the HERB CHF study in which patients with mild to moderate HF were randomised to either CSE 900 mg or placebo for 6 months. The primary outcome was time to progression of HF (HF death, hospitalisation, or sustained increase in diuretics) as assessed by log-rank tests and by Cox modelling.

RESULTS:

Progression of HF occurred in 46.6% of the CSE and 43.3% of the placebo groups (OR 1.14, 95% CI=0.56, 2.35: p=0.86). Patients receiving CSE were 3.9 times (95% CI=1.1-13.7: p=0.035) more likely to experience HF progression at baseline. In adjusted analysis, the risk of having early HF progression in the CSE group increased to 6.4 (95% CI=1.5, 26.5: p=0.011). In patients with LVEF< or =35%, those taking CSE were at significantly greater risk (3.2, 95% CI=1.3, 8.3: p=0.02) than the placebo group.

CONCLUSIONS:

CSE does not reduce heart failure progression in patients who have HF. CSE appears to increase the early risk of HF progression.

PMID:
18490196
[PubMed - indexed for MEDLINE]
PMCID:
PMC2577845
Free PMC Article

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