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Biol Psychiatry. 2008 Sep 15;64(6):491-7. doi: 10.1016/j.biopsych.2008.03.032. Epub 2008 May 19.

The vascular depression subtype: evidence of internal validity.

Author information

  • 1Department of Psychology, Queens College, City University of New York, Queens, New York 10032, USA. js2627@columbia.edu

Abstract

BACKGROUND:

Vascular depression has been proposed as a unique diagnostic subtype in late life, yet no study has evaluated whether the specified clinical features associated with the illness are jointly indicative of an underlying diagnostic class.

METHODS:

We applied latent class analysis to two independent clinical samples: the prospective, cohort design, Neurocognitive Outcomes of Depression in the Elderly (NCODE) study and the 8-week, multicenter, double blind, placebo-controlled Old-Old study.

RESULTS:

A two-class model consisting of vascular and nonvascular depressed patients provided an excellent fit to the data in both studies, chi(2)(6) = 2.02, p = .90 in the NCODE study and chi(2)(6) = 7.024, p = .32 in the Old-Old study. Although all of the proposed features of vascular depression were useful in identifying the illness, deep white matter lesion burden emerged with perfect sensitivity (1.00) and near-perfect specificity (.95), making it the only indicator necessary to determine class membership.

CONCLUSIONS:

These findings, replicated across two independent clinical samples, provide the first support for the internal validity of vascular depression as a subtype of late-life depression.

PMID:
18490003
[PubMed - indexed for MEDLINE]
PMCID:
PMC2597784
Free PMC Article

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