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Nature. 1991 Mar 28;350(6316):313-8.

Regulated import and degradation of a cytosolic protein in the yeast vacuole.

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  • 1Division of Biochemistry and Molecular Biology, Howard Hughes Medical Institute, University of California, Berkeley 94720.


The key regulatory enzyme in gluconeogenesis, fructose 1,6-bisphosphatase (FBPase) is subject to glucose-stimulated proteolytic degradation in Saccharomyces cerevisiae. This process involves the regulated transfer of FBPase directly from the cytosol into the vacuole or a vacuole-related organelle. Glucose may regulate the production of an FBPase receptor or import factor that is transported to the vacuole through the secretory pathway.

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