Nature. 1991 Mar 28;350(6316):313-8.

Regulated import and degradation of a cytosolic protein in the yeast vacuole.

Source

Division of Biochemistry and Molecular Biology, Howard Hughes Medical Institute, University of California, Berkeley 94720.

Abstract

The key regulatory enzyme in gluconeogenesis, fructose 1,6-bisphosphatase (FBPase) is subject to glucose-stimulated proteolytic degradation in Saccharomyces cerevisiae. This process involves the regulated transfer of FBPase directly from the cytosol into the vacuole or a vacuole-related organelle. Glucose may regulate the production of an FBPase receptor or import factor that is transported to the vacuole through the secretory pathway.

Comment in

Nature. 1994 May 26;369(6478):283-4.

PMID:: 1848921; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

Saccharomyces Genome Database

Supplemental Content

Save items

Related citations in PubMed

Isolation of degradation-deficient mutants defective in the targeting of fructose-1,6-bisphosphatase into the vacuole for degradation in Saccharomyces cerevisiae. [Genetics. 1996]
Isolation of degradation-deficient mutants defective in the targeting of fructose-1,6-bisphosphatase into the vacuole for degradation in Saccharomyces cerevisiae.
Hoffman M, Chiang HL. Genetics. 1996 Aug; 143(4):1555-66.
Biochemical analysis of fructose-1,6-bisphosphatase import into vacuole import and degradation vesicles reveals a role for UBC1 in vesicle biogenesis. [J Biol Chem. 2001]
Biochemical analysis of fructose-1,6-bisphosphatase import into vacuole import and degradation vesicles reveals a role for UBC1 in vesicle biogenesis.
Shieh HL, Chen Y, Brown CR, Chiang HL. J Biol Chem. 2001 Mar 30; 276(13):10398-406. Epub 2000 Dec 29.
In vitro reconstitution of glucose-induced targeting of fructose-1, 6-bisphosphatase into the vacuole in semi-intact yeast cells. [J Biol Chem. 1998]
In vitro reconstitution of glucose-induced targeting of fructose-1, 6-bisphosphatase into the vacuole in semi-intact yeast cells.
Shieh HL, Chiang HL. J Biol Chem. 1998 Feb 6; 273(6):3381-7.
Review Vacuole biogenesis in Saccharomyces cerevisiae: protein transport pathways to the yeast vacuole. [Microbiol Mol Biol Rev. 1998]
Review Vacuole biogenesis in Saccharomyces cerevisiae: protein transport pathways to the yeast vacuole.
Bryant NJ, Stevens TH. Microbiol Mol Biol Rev. 1998 Mar; 62(1):230-47.
Review Ultracytochemistry of the secretory pathway in Saccharomyces cerevisiae defies the established pathway model. [Electron Microsc Rev. 1991]
Review Ultracytochemistry of the secretory pathway in Saccharomyces cerevisiae defies the established pathway model.
Vorísek J. Electron Microsc Rev. 1991; 4(2):377-400.

See reviews... See all...

Cited by 39 PubMed Central articles

Vacuole import and degradation pathway: Insights into a specialized autophagy pathway. [World J Biol Chem. 2011]
Vacuole import and degradation pathway: Insights into a specialized autophagy pathway.
Alibhoy AA, Chiang HL. World J Biol Chem. 2011 Nov 26; 2(11):239-45.
The TOR complex 1 is required for the interaction of multiple cargo proteins selected for the vacuole import and degradation pathway. [Commun Integr Biol. 2010]
The TOR complex 1 is required for the interaction of multiple cargo proteins selected for the vacuole import and degradation pathway.
Alibhoy AA, Chiang HL. Commun Integr Biol. 2010 Nov; 3(6):594-6. Epub 2010 Nov 1.
Regulation of Vid-dependent degradation of FBPase by TCO89, a component of TOR Complex 1. [Int J Biol Sci. 2010]
Regulation of Vid-dependent degradation of FBPase by TCO89, a component of TOR Complex 1.
Yan Y, Kang B. Int J Biol Sci. 2010 Jul 2; 6(4):361-70. Epub 2010 Jul 2.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Regulated import and degradation of a cytosolic protein in the yeast vacuole.
Regulated import and degradation of a cytosolic protein in the yeast vacuole.
Nature. 1991 Mar 28 ;350(6316):313-8.

PubMed
Cost-utility analysis of varenicline versus existing smoking cessation strategie...
Cost-utility analysis of varenicline versus existing smoking cessation strategies using the BENESCO Simulation model: application to a population of US adult smokers.
Pharmacoeconomics. 2008 ;26(6):497-511.

PubMed
Antioxidant protection of resveratrol and catechin in Saccharomyces cerevisiae.
Antioxidant protection of resveratrol and catechin in Saccharomyces cerevisiae.
J Agric Food Chem. 2008 Jun 11 ;56(11):4268-72. Epub 2008 May 20 .

PubMed
Bupropion improves attention but does not affect impulsive behavior in healthy y...
Bupropion improves attention but does not affect impulsive behavior in healthy young adults.
Exp Clin Psychopharmacol. 2008 Apr ;16(2):113-23.

PubMed
[Incinerators, public health, financial interests: what some health professional...
[Incinerators, public health, financial interests: what some health professionals think].
Epidemiol Prev. 2008 Jan-Feb ;32(1):8-11.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: