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Nano Lett. 2008 Jun;8(6):1729-35. doi: 10.1021/nl0808132. Epub 2008 May 20.

Nanofluidic biosensing for beta-amyloid detection using surface enhanced Raman spectroscopy.

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  • 1Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843-3120, USA.


Trace detection of the conformational transition of beta-amyloid peptide (Abeta) from a predominantly alpha-helical structure to beta-sheet could have a large impact in understanding and diagnosing Alzheimer's disease. We demonstrate how a novel nanofluidic biosensor using a controlled, reproducible surface enhanced Raman spectroscopy active site was developed to observe Abeta in different conformational states during the Abeta self-assembly process as well as to distinguish Abeta from confounder proteins commonly found in cerebral spinal fluid.

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