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Nat Rev Drug Discov. 2008 Jun;7(6):517-29. doi: 10.1038/nrd2588. Epub 2008 May 16.

Form to function: current and future roles for atherosclerosis imaging in drug development.

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  • 1Department of Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK.

Abstract

There is a pressing need for robust imaging markers to assist in the development of drugs for the treatment of atherosclerosis. Conventional imaging methods provide quantitative and morphological data but may be inadequate for assessing a new generation of therapies that modify plaque biology directly. Here, we compare the main imaging modalities used to image atherosclerosis in the clinical-trial setting, and assess their ability to predict clinical outcomes for a given sample size. We consider how emerging molecular and cellular imaging techniques could offer the possibility to quantify changes in biological function at the level of the plaque, even without gross structural change.

PMID:
18483481
[PubMed - indexed for MEDLINE]
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