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Cancer Lett. 2008 Sep 18;268(2):187-201. doi: 10.1016/j.canlet.2008.03.055. Epub 2008 May 14.

Caveats of caveolin-1 in cancer progression.

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  • 1Department of Medicine II, Klinikum Rechts der Isar, Technical University of München, München, Germany.


Caveolin-1, an essential scaffold protein of caveolae and cellular transport processes, lately gained recognition as a stage- and tissue-specific tumor modulator in vivo. Patient studies and rodent models corroborated its janus-faced role as a tumor suppressor in non-neoplastic tissue, its down-regulation (loss of function) upon transformation and its re-expression (regain of function) in advanced-stage metastatic and multidrug resistant tumors. This review is focussed on the role of caveolin-1 in metastasis and angiogenesis and its clinical implications as a prognostic marker in cancer progression.

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