Chem Biol. 2008 May;15(5):421-3.

Computational design of enzymes.

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Institute of Biophysics and Physical Biochemistry, University of Regensburg, Regensburg, Germany.

Abstract

The de novo design of enzymes with activities not found in natural biocatalysts is a major challenge for molecular biology. Sophisticated computational methods have recently led to impressive progress in this exciting and rapidly evolving field (Röthlisberger et al., 2008; Jiang et al., 2008).

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Science. 2008 Mar 7;319(5868):1387-91.

PMID:: 18482694; [PubMed - indexed for MEDLINE]

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Enzymes

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Review De novo design of biocatalysts. [Curr Opin Chem Biol. 2002]
Review De novo design of biocatalysts.
Bolon DN, Voigt CA, Mayo SL. Curr Opin Chem Biol. 2002 Apr; 6(2):125-9.
Review Tailoring new enzyme functions by rational redesign. [Curr Opin Struct Biol. 2000]
Review Tailoring new enzyme functions by rational redesign.
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[Creation of enzymes using computdtional de novo design: retro-aldol enzymes]. [Tanpakushitsu Kakusan Koso. 2009]
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Cited by 3 PubMed Central articles

The influence of protein dynamics on the success of computational enzyme design. [J Am Chem Soc. 2009]
The influence of protein dynamics on the success of computational enzyme design.
Ruscio JZ, Kohn JE, Ball KA, Head-Gordon T. J Am Chem Soc. 2009 Oct 7; 131(39):14111-5.
Designing new cellular signaling pathways. [Chem Biol. 2009]
Designing new cellular signaling pathways.
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TransCent: computational enzyme design by transferring active sites and considering constraints relevant for catalysis. [BMC Bioinformatics. 2009]
TransCent: computational enzyme design by transferring active sites and considering constraints relevant for catalysis.
Fischer A, Enkler N, Neudert G, Bocola M, Sterner R, Merkl R. BMC Bioinformatics. 2009 Feb 10; 10:54. Epub 2009 Feb 10.

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