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Expert Opin Ther Targets. 2008 Jun;12(6):705-15. doi: 10.1517/14728222.12.6.705 .

Targeting TrkB neurotrophin receptor to treat depression.

Author information

  • 1University of Helsinki, Neuroscience Center, P.O. Box 56, Helsinki, Finland.

Abstract

BACKGROUND:

An increasing number of findings point out the key role of the BDNF (brain-derived neurotrophic factor) receptor, tyrosine kinase receptor B (TrkB), in the regulation of antidepressant drug actions. Therefore, targeting TrkB receptors might be a rational strategy to develop novel antidepressant drugs.

OBJECTIVE/METHODS:

In this review we will discuss several approaches to targeting the TrkB receptor using existing or novel drugs. We will mainly concentrate on the following issues: i) synthesis, release and cleavage of neurotrophins; ii) augmentation of the actions of neurotrophins; iii) synthesis of TrkB; iv) developing agonists for TrkB; and v) TrkB transactivation.

CONCLUSIONS:

Different molecular approaches can be used to screen antidepressant drugs acting through TrkB receptors but it remains to be seen whether they demonstrate therapeutic antidepressant effects.

PMID:
18479217
[PubMed - indexed for MEDLINE]
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