Figure 4Variances of the SR curves change with the conformation interconversion rate, *r*_{int}, with different sets of disordered parameters.

Upper: *r*_{int} vs. relative variances of the critical signal level. The critical signal level is defined as [*S*]_{ti} at half the plateau responses (i.e. [*R*_{P}]_{i} = [*R*_{P}]_{i}([*S*]_{t}→∞)/2). Bottom: *r*_{int} vs. relative variances of the plateau response (i.e. [*R*_{P}]_{i}([*S*]_{t}→∞). Different sets of disordered parameters denoted in the legend: a) *k*_{2} is computed from the gamma distribution with *a* = 4, *b*_{2} = 1/*a*; b) *k*_{1}′ is computed from the gamma distribution with *a* = 4, *b*_{1}′ = 10/*a*; c) *k*_{1} is computed from the gamma distribution with *a* = 4, *b*_{1} = 0.008/*a*; d) all the enzymatic reaction rates, *k*_{1}, *k*_{1}′ and *k*_{2}, are computed from the gamma distribution with (*a*,*b*_{1};*a*,*b*_{1}′;*a*,*b*_{2}); e) and *k*_{2}, come from the gamma distribution with (*a*,*b*_{1};*a*,*b*_{2}), but *k*_{1}′ comes from the gamma distribution with (*a*/2,2*b*_{1}′). The parameters of the gamma distributions in case a, b, c are chosen so that the mean rates equal the ones used in absence of the dynamic disorder. Note that the parameter *a*, which determines the width of the distribution, were chosen the same except in the last case for *k*_{1}′.

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