Biochem Biophys Res Commun. 1991 Feb 28;175(1):220-8.

Hypervariable regions in the putative glycoprotein of hepatitis C virus.

Hijikata M, Kato N, Ootsuyama Y, Nakagawa M, Ohkoshi S, Shimotohno K.

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Virology Division, National Cancer Center Research Institute, Tokyo, Japan.

Abstract

A comparison of the sequences of the putative glycoprotein region in three independent cDNA clones of hepatitis C virus and of sequences of four other clones revealed extensive genetic variation clustered and interspersed with highly conserved amino acid sequences. We obtained evidence for two hypervariable regions in the putative envelope glycoprotein, one region was assumed to be a potential antigenic site, as deduced from the hydrophilicity and analyses of secondary structures. These observations suggest the existence of a large pool of antigenic variants of hepatitis C virus, in Japan.

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Hypervariable regions in the putative glycoprotein of hepatitis C virus.

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