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J Invest Dermatol. 2008 Jun;128(6):1355-8. doi: 10.1038/jid.2008.123.

Beta-papillomavirus infection and skin cancer.

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  • 1Department of Dermatology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.


The development of highly sensitive PCR techniques and multiplex bead-based Luminex platforms has accelerated the search for a specific role of human papilloma viruses in the development of squamous cell carcinoma. Human papillomaviruses are most likely indirectly involved in this process by facilitating UV-related carcinogenesis via preventing UV-induced apoptosis or impairing DNA repair, but other mechanisms are also possible.

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