PURPOSE OF REVIEW: In the last 10 years, otolaryngologists and allergists have become increasingly aware of migraine headaches in their practices. This is partially due to a better understanding of the high incidence of migraine and a realization that the majority of patients presenting as 'sinus headache' are actually suffering from migraine headaches. Considering that the incidence of migraine is approximately 20% in women and 6% in men and that 10-30% of people have allergies (US Department of Health and Human Services. Evidence Report/Technology Assessment No. 54; May 2002. AHRQ Publication No. 02-E024. pp. 1-198), there is obviously a large population of patients who suffer from both conditions. The question then arises that are migraine and allergy comorbid conditions, or is any association between the two a random occurrence? RECENT FINDINGS: The present study addresses this association, which has remained controversial for over 100 years. Newer studies focusing on familial trends, shared biochemical pathways and underlying mechanisms are presented. RELEVANCE: This study will provide a foundation to support future clinical studies.