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J Endocrinol Invest. 2008 Apr;31(4):364-70.

Bone involvement in exogenous hypercortisolism.

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  • 1Department of Rheumatology, Gaetano Pini Institute, University of Milan, 20122 Milan, Italy. sinigagl@gpini.it


Corticosteroids remain a key component in the management of many disorders. Bone loss resulting from long-term administration of these drugs is common and osteoporosis induced by corticosteroids is the most frequent cause of secondary osteoporosis in nearly 50% of individuals on chronic corticosteroid therapy suffering from an osteoporotic fracture at some point. This article reviews the epidemiology and pathogenesis of glucocorticoid-induced osteoporosis.

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