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    Arch Neurol. 2008 May;65(5):589-92.

    Diagnostic and pathogenic significance of glutamate receptor autoantibodies.

    Source

    Department of Neurology, University of California, Davis, School of Medicine, Sacramento, CA 95817, USA. david.pleasure@ucdmc.ucdavis.edu

    Abstract

    Autoantibodies against glutamate receptors, first reported in Rasmussen encephalitis, have been observed in other focal epilepsies, central nervous system ischemic infarcts, transient ischemic attacks, sporadic olivopontocerebellar atrophy, systemic lupus erythematosus, and paraneoplastic encephalopathies. The detection of glutamate receptor autoantibodies is not useful in the evaluation of Rasmussen encephalitis but may be a biomarker for brain ischemia, and it is helpful in diagnosing certain paraneoplastic encephalopathies. Passive transfer of glutamate receptor autoantibodies from patients with systemic lupus erythematosus or paraneoplastic encephalopathy suggests that glutamate receptor autoantibodies can actively contribute to neurologic dysfunction.

    PMID:
    18474732
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2898900
    Free PMC Article

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