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Curr Psychiatry Rep. 2008 Apr;10(2):116-22.

Vagus nerve stimulation: can it be used in adolescents or children with treatment-resistant depression?

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  • 1Children's Hospital of Philadelphia, 3440 Market Street, Philadelphia, PA 19104, USA. yuz@email.chop.edu


Vagus nerve stimulation (VNS) therapy has been approved by the US Food and Drug Administration for treatment-resistant depression in patients 18 years of age and older and for intractable epilepsy. Long-term studies suggest VNS has an antidepressant effect in adults. This paper reviews the available clinical data for VNS therapy. Its potential application for treatment-resistant depression in adolescents and children is also discussed.

[PubMed - indexed for MEDLINE]
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