Carbonyl-scavenging drugs & protection against carbonyl stress-associated cell injury

P C Burcham; L M Kaminskas; D Tan; S M Pyke

doi:10.2174/138955708783955953

Carbonyl-scavenging drugs & protection against carbonyl stress-associated cell injury

Mini Rev Med Chem. 2008 Apr;8(4):319-30. doi: 10.2174/138955708783955953.

Authors

P C Burcham¹, L M Kaminskas, D Tan, S M Pyke

Affiliation

¹ Pharmacology & Anaesthesiology Unit, School of Medicine & Pharmacology, The University of Western Australia, Nedlands, WA, Australia. philip.burcham@uwa.edu.au

PMID: 18473924
DOI: 10.2174/138955708783955953

Abstract

This mini-review highlights the chemical and cytoprotective properties of various hydralazine analogues that block the induction of cell death by acrolein, a highly toxic contributor to "carbonyl stress" during a diverse range of human diseases. Recent work on the action of hydralazine against various carbonyl-mediated pathologies is also reviewed.

Publication types

Review

MeSH terms

Acrolein / antagonists & inhibitors*
Acrolein / toxicity
Alzheimer Disease / chemically induced
Alzheimer Disease / drug therapy
Animals
Atherosclerosis / chemically induced
Atherosclerosis / drug therapy
Cell Death / drug effects
Free Radical Scavengers / chemistry
Free Radical Scavengers / pharmacology*
Free Radical Scavengers / therapeutic use
Humans
Hydralazine / analogs & derivatives
Hydralazine / chemistry
Hydralazine / pharmacology*
Liver Diseases, Alcoholic / drug therapy
Oxidative Stress / drug effects
Protective Agents / chemistry
Protective Agents / pharmacology*
Protective Agents / therapeutic use
Spinal Cord Injuries / chemically induced
Spinal Cord Injuries / drug therapy

Substances

Free Radical Scavengers
Protective Agents
Hydralazine
Acrolein