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Ann Oncol. 2008 Sep;19(9):1634-8. doi: 10.1093/annonc/mdn182. Epub 2008 May 7.

Biologic features and treatment outcome of secondary acute lymphoblastic leukemia--a review of 101 cases.

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  • 1Leukemia Section, Department of Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA.

Abstract

BACKGROUND:

Secondary acute lymphoblastic leukemia (sALL) is a rare disease and its biologic features are not well characterized.

PATIENTS AND METHODS:

We describe a cohort of seven patients and discuss 94 additional cases from the literature for whom biological parameters were described. Cases with incomplete data were excluded.

RESULTS:

Hodgkin's disease (HD) was more common in the 18-59 age group while breast and prostate cancers were prevalent only in the >or=18-year-old patients. The time interval to develop sALL was similar among all age groups but was significantly longer for HD and neuroblastoma primary diagnoses and sALL with complex karyotype. T-cell immunophenotype was more common in the <18 age group. Complete remission was infrequent in the >or=60 age group. The overall survival was poor for all sALL regardless of age, primary diagnoses, cytogenetic subgroups, or immunophenotype. Allogeneic transplantation most probably represents the only chance of cure.

CONCLUSION:

Better identification of prognostic factors to prevent the occurrence of sALL is indicated.

PMID:
18467310
[PubMed - indexed for MEDLINE]
PMCID:
PMC2733065
Free PMC Article
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