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Genome Biol. 2008 Apr 30;9(4):216. doi: 10.1186/gb-2008-9-4-216.

The AAA+ superfamily of functionally diverse proteins.

Author information

  • 1Department of Biochemistry, University of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.

Abstract

SUMMARY:

The AAA+ superfamily is a large and functionally diverse superfamily of NTPases that are characterized by a conserved nucleotide-binding and catalytic module, the AAA+ module. Members are involved in an astonishing range of different cellular processes, attaining this functional diversity through additions of structural motifs and modifications to the core AAA+ module.

PMID:
18466635
[PubMed - indexed for MEDLINE]
PMCID:
PMC2643927
Free PMC Article

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