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Genome Biol. 2008 Apr 25;9(4):217. doi: 10.1186/gb-2008-9-4-217.

New tricks for old NODs.

Author information

  • 1Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, CA 90095, USA.

Abstract

Recent work has identified the human NOD-like receptor NLRX1 as a negative regulator of intracellular signaling leading to type I interferon production. Here we discuss these findings and the questions and implications they raise regarding the function of NOD-like receptors in the antiviral response.

PMID:
18466630
[PubMed - indexed for MEDLINE]
PMCID:
PMC2643928
Free PMC Article

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