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1: BMC Proc. 2007;1 Suppl 1:S43. Epub 2007 Dec 18.Click here to read Click here to read Links

Linkage, case-control association, and family-based association tests for complex disorders.

Suarez BK, Culverhouse R, Jin CH, Hinrichs A.

Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, St, Louis, Missouri 63110, USA. bks@themfs.wustl.edu.

ABSTRACT : We carried out an analysis of the Genetic Analysis Workshop 15 simulated Problem 3 data. We restricted ourselves to the present/absent phenotype. Linkage analysis revealed a very strong signal on chromosome 6. Association analysis revealed additional susceptible loci located on chromosomes 11 and 18. The latter two signals were subsequently verified with linkage analysis - but only after 20 replicates were pooled. Analysis of linkage disequilibrium patterns, in concert with family-based association tests, led us to infer the presence of a second chromosome 6 locus located in the vicinity of single-nucleotide polymorphisms 160-162. These analyses were carried out without knowledge of the model used to generate the simulation.

PMID: 18466542 [PubMed - in process]

PMCID: PMC2367550

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