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Pharmacogenomics. 2008 May;9(5):501-4. doi: 10.2217/14622416.9.5.501.

Serotonin type 3 receptor genes: HTR3A, B, C, D, E.

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  • 1Department of Human Molecular Genetics, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany.


The 5-HT(3) receptor is a ligand-gated ion channel composed of five subunits. To date, five different human subunits are known, 5-HT(3AE), which are encoded by the serotonin receptor genes HTR3A, HTR3B, HTR3C, HTR3D and HTR3E, respectively. Functional receptors are pentameric complexes of diverse composition. Different receptor subtypes seem to be involved in chemotherapy-induced nausea and vomiting (CINV), irritable bowel syndrome and psychiatric disorders. 5-HT(3) receptor antagonists are established in the therapy of CINV and irritable bowel syndrome. HTR3A and HTR3B polymorphisms may also contribute to the etiology of psychiatric disorders and serve as predictors in CINV and in the medical treatment of psychiatric patients.

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