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Clin Infect Dis. 2008 Jun 15;46(12):e142-5. doi: 10.1086/588483.

Secondary syphilis with ocular manifestations in older adults.

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  • 1United States Naval Medical Research Center Detachment, Lima, Peru.


We describe 4 patients (age, >50 years) with secondary syphilis. All patients presented with ocular syphilis, and 2 presented with syphilis-negative rapid plasma reagin titers due to a prozone phenomenon. Three male patients reported sildenafil use. The presentation of these patients with ocular syphilis suggests the need for additional clinical studies involving older patients.

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