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Cell Metab. 2008 May;7(5):361-2. doi: 10.1016/j.cmet.2008.04.009.

The CAMplexities of central ghrelin.

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  • 1Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA. mark.sleeman@regeneron.com

Abstract

The gut hormone ghrelin is known to activate hypothalamic AMPK, a crucial metabolic sensor controlling energy balance. In this issue of Cell Metabolism, Anderson et al. (2008) show that CaMKK2 mediates this effect by forming a unique complex of AMPKalpha/beta with acetyl-CoA carboxylase (ACC) in a pathway distinct from the more established AMP/LKB1 pathway.

PMID:
18460326
[PubMed - indexed for MEDLINE]
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