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BMC Bioinformatics. 2008 Apr 29;9 Suppl 5:S2. doi: 10.1186/1471-2105-9-S5-S2.

Gene Ontology annotations: what they mean and where they come from.

Author information

  • 1The Jackson Laboratory, Bar Harbor, ME, USA. dph@informatics.jax.org

Abstract

To address the challenges of information integration and retrieval, the computational genomics community increasingly has come to rely on the methodology of creating annotations of scientific literature using terms from controlled structured vocabularies such as the Gene Ontology (GO). Here we address the question of what such annotations signify and of how they are created by working biologists. Our goal is to promote a better understanding of how the results of experiments are captured in annotations, in the hope that this will lead both to better representations of biological reality through annotation and ontology development and to more informed use of GO resources by experimental scientists.

PMID:
18460184
[PubMed - indexed for MEDLINE]
PMCID:
PMC2367625
Free PMC Article

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