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Graefes Arch Clin Exp Ophthalmol. 2008 Aug;246(8):1117-22. doi: 10.1007/s00417-008-0845-0. Epub 2008 May 6.

Fate mapping of neural crest cells during eye development using a protein 0 promoter-driven transgenic technique.

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  • 1Department of Ophthalmology and Visual Science, Kumamoto University Graduate School of Medical Sciences, 1-1-1, Honjo, 860-8556, Kumamoto, Japan.



To map neural crest cell fate during eye development.


Neural crest cells were tracked in developing mouse eyes using a transgene expressing Cre recombinase controlled by the Protein 0 promoter and a Rosa26 Cre-responsive reporter gene that produced beta-galactosidase after Cre-mediated recombination.


beta-galactosidase-positive cells were detected in the periocular segment on embryonic day (E) 9.5. Several neural crest cell-derived tissues including corneal stroma, corneal endothelium, iridocorneal angle, ciliary body, primary vitreous and eyelid were strongly stained on E13.5-E18.5. The staining decreased in the corneal stroma after birth, but persisted in the presumptive iridocorneal angle.


Protein 0-Cre transgenic mice offer a conditional knock-out strategy to investigate anterior eye segment differentiation.

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