A different TIPE of immune homeostasis

Eric C Freundt; Nicolas Bidere; Michael J Lenardo

doi:10.1016/j.cell.2008.04.017

A different TIPE of immune homeostasis

Cell. 2008 May 2;133(3):401-2. doi: 10.1016/j.cell.2008.04.017.

Authors

Eric C Freundt¹, Nicolas Bidere, Michael J Lenardo

Affiliation

¹ Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

Proteins with death effector domains (DED) are key signal transducers involved in cell death and inflammation. In this issue of Cell, Sun et al. (2008) describe TIPE2, a DED protein that negatively regulates both T cell receptor and Toll-like receptor signaling. These findings reveal a new element critical to the maintenance of homeostasis in both the adaptive and innate immune systems.

Publication types

Comment

MeSH terms

Animals
Caspases / metabolism
Cell Death
Homeostasis*
Humans
Immunity, Innate*
Intracellular Signaling Peptides and Proteins / chemistry
Intracellular Signaling Peptides and Proteins / immunology*
Mice
Protein Structure, Tertiary
Signal Transduction
Toll-Like Receptors / immunology

Substances

Intracellular Signaling Peptides and Proteins
TIPE2 protein, mouse
Toll-Like Receptors
Caspases

Grants and funding

Z01 AI000718-13/ImNIH/Intramural NIH HHS/United States