J Cell Physiol. 2008 Aug;216(2):327-31.

Insights into cellular microRNAs and human immunodeficiency virus type 1 (HIV-1).

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Department of Biochemistry and Molecular Biology, George Washington University School of Medicine, Washington, District of Columbia, USA.

Abstract

Recent findings suggest that mammalian microRNAs (miRNAs) may influence viral replication in host cells. Studies on HIV-1 infection have contributed in part to the development of this notion. Herein, we review, in brief, some of the evidence supportive of an interplay between human miRNAs and HIV-1 in cells. Several cellular miRNAs potentially act to restrict HIV-1 replication, and the virus has countermeasures to evade such restriction.

PMID:: 18452151; [PubMed - indexed for MEDLINE]

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