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Br J Psychiatry. 2008 May;192(5):356-61. doi: 10.1192/bjp.bp.107.043398.

Affective modulation of anterior cingulate cortex in young people at increased familial risk of depression.

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  • 1University Department of Psychiatry, Warneford Hospital, Oxford, UK.

Abstract

BACKGROUND:

We previously found that children of parents with depression showed impaired performance on a task of emotional categorisation.

AIMS:

To test the hypothesis that children of parents with depression would show abnormal neural responses in the anterior cingulate cortex, a brain region involved in the integration of emotional and cognitive information.

METHOD:

Eighteen young people (mean age 19.8 years) with no personal history of depression but with a biological parent with a history of major depression (FH+ participants) and 16 controls (mean age 19.9 years) underwent functional magnetic resonance imaging while completing an emotional counting Stroop task.

RESULTS:

Controls showed significant activation in the pregenual anterior cingulate cortex to both positive and negative words during the emotional Stroop task. This activation was absent in FH+ participants.

CONCLUSIONS:

Our findings show that people at increased familial risk of depression demonstrate impaired modulation of the anterior cingulate cortex in response to emotionally valenced stimuli.

PMID:
18450659
[PubMed - indexed for MEDLINE]
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