Arch Neurol. 1991 Dec;48(12):1300-3.

Frontal lobe dysfunction following infarction of the left-sided medial thalamus.

Sandson TA, Daffner KR, Carvalho PA, Mesulam MM.

Source

Behavioral Neurology Unit, Beth Israel Hospital, Boston, MA 02215.

Abstract

We treated a 62-year-old woman who developed a dramatic change in personality and behavior following a discrete left-sided medial thalamic infarction involving the dorsomedial nucleus. Neuropsychological testing demonstrated severe impairment of complex executive behaviors that are usually associated with frontal lobe function. Electroencephalography and single-photon emission computed tomography strongly implicated dysfunction of the ipsilateral frontal lobe. This case further supports a functional and physiologic thalamofrontal linkage as part of a broader cerebral network modulating complex human behavior.

PMID:: 1845037; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms

Publication Types

Case Reports

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Supplemental Content

Icon for Silverchair Information Systems

Save items

Related citations in PubMed

Hypersexuality following bilateral thalamic infarction: case report. [Arq Neuropsiquiatr. 2006]
Hypersexuality following bilateral thalamic infarction: case report.
Mutarelli EG, Omuro AM, Adoni T. Arq Neuropsiquiatr. 2006 Mar; 64(1):146-8. Epub 2006 Apr 5.
[Amnesia, confabulation and nonaphasic misnaming after left thalamic infarct]. [No To Shinkei. 2003]
[Amnesia, confabulation and nonaphasic misnaming after left thalamic infarct].
Hayashi R, Ohashi M, Watanabe R, Mimura M, Katsumata Y. No To Shinkei. 2003 Jun; 55(6):530-5.
Utilization behavior after right thalamic infarction. [Eur Neurol. 1995]
Utilization behavior after right thalamic infarction.
Hashimoto R, Yoshida M, Tanaka Y. Eur Neurol. 1995; 35(1):58-62.
Review Strategic infarcts in vascular dementia. A clinical and brain imaging experience. [Arzneimittelforschung. 1995]
Review Strategic infarcts in vascular dementia. A clinical and brain imaging experience.
Tatemichi TK, Desmond DW, Prohovnik I. Arzneimittelforschung. 1995 Mar; 45(3A):371-85.
Review Thalamic ataxia. [J Neurol. 1992]
Review Thalamic ataxia.
Melo TP, Bogousslavsky J, Moulin T, Nader J, Regli F. J Neurol. 1992 Jul; 239(6):331-7.

See reviews... See all...

Cited by 4 PubMed Central articles

Working memory in 8 Kleine-Levin syndrome patients: an fMRI study. [Sleep. 2009]
Working memory in 8 Kleine-Levin syndrome patients: an fMRI study.
Engström M, Vigren P, Karlsson T, Landtblom AM. Sleep. 2009 May; 32(5):681-8.
Thalamofrontal circuitry and executive dysfunction in recent-onset juvenile myoclonic epilepsy. [Epilepsia. 2009]
Thalamofrontal circuitry and executive dysfunction in recent-onset juvenile myoclonic epilepsy.
Pulsipher DT, Seidenberg M, Guidotti L, Tuchscherer VN, Morton J, Sheth RD, Hermann B. Epilepsia. 2009 May; 50(5):1210-9. Epub 2009 Jan 17.
Review Frontal-subcortical circuitry and behavior. [Dialogues Clin Neurosci. 2007]
Review Frontal-subcortical circuitry and behavior.
Bonelli RM, Cummings JL. Dialogues Clin Neurosci. 2007; 9(2):141-51.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Frontal lobe dysfunction following infarction of the left-sided medial thalamus.
Frontal lobe dysfunction following infarction of the left-sided medial thalamus.
Arch Neurol. 1991 Dec ;48(12):1300-3.

PubMed
The possible role of ammonia toxicity on the exposure, deposition, retention, an...
The possible role of ammonia toxicity on the exposure, deposition, retention, and the bioavailability of nicotine during smoking.
Food Chem Toxicol. 2008 Jun ;46(6):1863-81. Epub 2008 Mar 4 .

PubMed
Excitotoxicity and dopaminergic dysfunction in the acquired immunodeficiency syn...
Excitotoxicity and dopaminergic dysfunction in the acquired immunodeficiency syndrome dementia complex. Therapeutic implications.
Arch Neurol. 1991 Dec ;48(12):1281-4.

PubMed
Comparison of alpha-Type-1 polarizing and standard dendritic cell cytokine cockt...
Comparison of alpha-Type-1 polarizing and standard dendritic cell cytokine cocktail for maturation of therapeutic monocyte-derived dendritic cell preparations from cancer patients.
Vaccine. 2008 Jun 2 ;26(23):2824-32. Epub 2008 Apr 11 .

PubMed
"Left without being seen": a national profile of children who leave the emergenc...
"Left without being seen": a national profile of children who leave the emergency department before evaluation.
Ann Emerg Med. 2008 Dec ;52(6):599-605. Epub 2008 May 1 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: