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    J Autism Dev Disord. 2008 Nov;38(10):1827-36. Epub 2008 May 1.

    Regression, developmental trajectory and associated problems in disorders in the autism spectrum: the SNAP study.

    Baird G, Charman T, Pickles A, Chandler S, Loucas T, Meldrum D, Carcani-Rathwell I, Serkana D, Simonoff E.

    Source

    Newcomen Centre, Guy's & St. Thomas' NHS Foundation Trust, London, SE1 9RT, UK. gillian.baird@gstt.nhs.uk

    Abstract

    We report rates of regression and associated findings in a population derived group of 255 children aged 9-14 years, participating in a prevalence study of autism spectrum disorders (ASD); 53 with narrowly defined autism, 105 with broader ASD and 97 with non-ASD neurodevelopmental problems, drawn from those with special educational needs within a population of 56,946 children. Language regression was reported in 30% with narrowly defined autism, 8% with broader ASD and less than 3% with developmental problems without ASD. A smaller group of children were identified who underwent a less clear setback. Regression was associated with higher rates of autistic symptoms and a deviation in developmental trajectory. Regression was not associated with epilepsy or gastrointestinal problems.

    PMID:
    18449635
    [PubMed - indexed for MEDLINE]

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        Bolton PF, Carcani-Rathwell I, Hutton J, Goode S, Howlin P, Rutter M. Br J Psychiatry. 2011 Apr; 198(4):289-94.

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