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Psychosomatics. 2008 May-Jun;49(3):243-8. doi: 10.1176/appi.psy.49.3.243.

Determinants of quality of life in Marfan syndrome.

Author information

  • 1DSSAeP, Sezione di Psichiatria, Universit√† di Pavia, Pavia, Italy. p.fusar@libero.it

Abstract

BACKGROUND:

Marfan syndrome (MFS) is a rare, heritable disorder that affects connective tissue. Men and women are equally affected. Clinical manifestations involve multiple sites, especially bones and ligaments and heart and blood vessels.

OBJECTIVE:

Authors sought to investigate quality of life (QoL) in MFS patients, assessing positive and negative sociodemographic factors and self-perceived well-being and functional status.

METHOD:

Thirty-six patients affected by MFS were interviewed and were administered the SF-36 psychometric questionnaire.

RESULTS:

Subjects affected by MFS reported an impaired quality of life in the psychological domain but not in the physical domain, as compared with a healthy population. Being male and older was significantly associated with a poorer perceived mental QoL.

CONCLUSION:

The authors found that MFS negatively influences QoL, increases psychological distress, and may be a possible risk for some psychiatric disorders.

PMID:
18448780
[PubMed - indexed for MEDLINE]
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