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Psychosomatics. 2008 May-Jun;49(3):243-8. doi: 10.1176/appi.psy.49.3.243.

Determinants of quality of life in Marfan syndrome.

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  • 1DSSAeP, Sezione di Psichiatria, Universit√† di Pavia, Pavia, Italy.



Marfan syndrome (MFS) is a rare, heritable disorder that affects connective tissue. Men and women are equally affected. Clinical manifestations involve multiple sites, especially bones and ligaments and heart and blood vessels.


Authors sought to investigate quality of life (QoL) in MFS patients, assessing positive and negative sociodemographic factors and self-perceived well-being and functional status.


Thirty-six patients affected by MFS were interviewed and were administered the SF-36 psychometric questionnaire.


Subjects affected by MFS reported an impaired quality of life in the psychological domain but not in the physical domain, as compared with a healthy population. Being male and older was significantly associated with a poorer perceived mental QoL.


The authors found that MFS negatively influences QoL, increases psychological distress, and may be a possible risk for some psychiatric disorders.

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