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Expert Opin Investig Drugs. 2008 May;17(5):661-8. doi: 10.1517/13543784.17.5.661 .

Polymyxin B: a new strategy for multidrug-resistant Gram-negative organisms.

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  • 1Chongqing Medical University, The First Affiliated Hospital, Department of Infectious Diseases, Chongqing 400016, China.

Abstract

BACKGROUND:

There has been a renewed interest in using polymyxin B as a last resort therapeutic option, due to emergence of multidrug-resistant Gram-negative bacteria. Despite being available for clinical use for decades, there is still a very limited understanding on many aspects of this agent.

OBJECTIVE:

To review what is known about polymyxin B and to identify missing information or gaps for future investigations.

METHODS:

Pertinent information was reviewed from published literature in English.

RESULTS/CONCLUSION:

For optimal use of polymyxin B, a more thorough understanding is needed on standardized susceptibility testing, serum and tissue concentrations achieved, antibacterial activity when polymyxin B is combined with other agents, and mechanisms of resistance. A more precise characterization of the relationship between drug concentration and toxicity is also required.

PMID:
18447592
[PubMed - indexed for MEDLINE]
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