J Biopharm Stat. 1991;1(1):103-20.

An overview of statistical issues and methods of meta-analysis.

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Department of Biostatistics, School of Public Health, University of North Carolina, Chapel Hill 27599-7400.

Abstract

A meta-analysis is a statistical analysis of the data from some collection of studies in order to synthesize the results. In this paper we discuss issues that frequently arise in meta-analysis and give an overview of the methods used, with particular attention to the use of fixed- and random-effects approaches. The methods are then applied to two sample datasets.

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