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Clin Infect Dis. 2008 Apr 15;46(8):e78-82. doi: 10.1086/529387.

CD4+ T cell depletion in an untreated HIV type 1-infected human leukocyte antigen-B*5801-positive patient with an undetectable viral load.

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  • 1Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

Abstract

We report a case of a patient infected with human immunodeficiency virus type 1 (HIV-1) for 20 years who has experienced CD4(+) T cell depletion in spite of maintaining undetectable viral loads. Our data suggest that immune activation can cause CD4(+) T cell depletion even when HIV-1 replication appears to be controlled by host factors.

PMID:
18444844
[PubMed - indexed for MEDLINE]
PMCID:
PMC2664682
Free PMC Article
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