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J Exp Med. 2008 May 12;205(5):1099-108. doi: 10.1084/jem.20070850. Epub 2008 Apr 28.

A role for sex chromosome complement in the female bias in autoimmune disease.

Author information

  • 1Department of Neurology, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Abstract

Most autoimmune diseases are more common in women than in men. This may be caused by differences in sex hormones, sex chromosomes, or both. In this study, we determined if there was a contribution of sex chromosomes to sex differences in susceptibility to two immunologically distinct disease models, experimental autoimmune encephalomyelitis (EAE) and pristane-induced lupus. Transgenic SJL mice were created to permit a comparison between XX and XY within a common gonadal type. Mice of the XX sex chromosome complement, as compared with XY, demonstrated greater susceptibility to both EAE and lupus. This is the first evidence that the XX sex chromosome complement, as compared with XY, confers greater susceptibility to autoimmune disease.

PMID:
18443225
[PubMed - indexed for MEDLINE]
PMCID:
PMC2373842
Free PMC Article

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